It is not known whether procaine is safe when taken by mouth. It can cause some side effects including heartburn, migraines, and a serious condition called systemic lupus erythematosus (SLE). SLE causes a variety of symptoms including joint pain, rashes, lung problems, and many other symptoms.
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Procaine is safe when the prescription-only product is given as a shot by a healthcare professional as a local anesthetic.
: It'sto use procaine for self-medication if you are pregnant. If you are breast-feeding, it is also best to avoid using procaine. Not enough is known about how it might affect the nursing infant.
Myasthenia gravis, a progressive disease that weakens the muscles: If you have myasthenia gravis, you should not be given procaine intravenously (by IV).
Pseudocholinesterase deficiency, an inherited disorder: People with this disorder are sensitive to certain anesthetic drugs. If you have this disorder, you should not be given procaine by injection.
Systemic lupus erythematosus (SLE): Procaine might make this condition worse. Don't use procaine if you have SLE.
Interaction Rating:Do not take this combination.
Digoxin (Lanoxin) helps the heart beat more strongly. Digoxin (Lanoxin) can also control how fast the heart beats. Getting a procaine injection can slow the heartbeat. Taking digoxin with procaine might cause your heartbeat to be too slow.
Muscle relaxantsInteraction Rating: Major Do not take this combination.Interaction Rating:Do not take this combination.
Procaine is given as a shot to numb pain. Taking procaine with some muscle relaxants can cause the numbing to last too long. Before getting a procaine injection tell your doctor if you are taking any muscle relaxants.
Some of these muscle relaxants include atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.
SuccinylcholineInteraction Rating: Major Do not take this combination.Interaction Rating:Do not take this combination.
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Procaine is injected and used to numb pain. Taking procaine with succinylcholine can cause the numbing to last too long.
Aminosalicylic acidInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.Interaction Rating:Be cautious with this combination.Talk with your health provider.
The body breaks down procaine to get rid of it. Procaine is broken down to a chemical called aminobenzoic acid. Aminobenzoic acid might decrease the effectiveness of aminosalicylic acid. Taking procaine along with aminosalicylic acid might decrease the effectiveness of aminosalicylic acid.
Antibiotics (Sulfonamide antibiotics)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.Interaction Rating:Be cautious with this combination.Talk with your health provider.
The body changes procaine to para-aminobenzoic acid (PABA). PABA can decrease the effectiveness of certain antibiotics called sulfonamides.
Some of these antibiotics include sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and trimethoprim/sulfamethoxazole (Bactrim, Septra).
The following doses have been studied in scientific research:
BY INJECTION:
79
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